|
|
- Ishizuki Y, Hirooka Y, Murata Y, Togashi K.
- Nippon Naibunpi Gakkai Zasshi 1991 May 20 67:5 622-9 (Japanese)
-
- Abstract
- To elucidate whether soybeans would suppress the thyroid function
in healthy adults, we selected 37 subjects who had never had goiters
or serum antithyroid antibodies. They were given 30g of soybeans
everyday and were divided into 3 groups subject to age and duration
of soybean administration. In group 1, 20 subjects were given
soybeans for 1 month. Groups 2 and 3 were composed of 7 younger
subjects (mean 29 y.o.) and 10 elder subjects (mean 61 y.o.) respectively,
and the subjects belonging to these groups received soybeans for
3 months. The Wilcoxon-test and t-test were used in the statistical
analyses. In all groups, the various parameters of serum thyroid
hormones remained unchanged by taking soybeans, however TSH levels
rose significantly although they stayed within normal ranges.
The TSH response after TRH stimulation in group 3 revealed a more
significant increase than that in group 2, although inorganic
iodide levels were lowered during the administration of the soybeans.
We have not obtained any significant correlation between serum
inorganic iodide and TSH. Hypometabolic symptoms (malaise, constipation,
sleepiness) and goiters appeared in half the subjects in groups
2 and 3 after taking soybeans for 3 months, but they disappeared
1 month after the cessation of soybean ingestion. These findings
suggested that excessive soybean ingestion for a certain duration
might suppress thyroid function and cause goiters in healthy people,
especially elderly subjects.
|
